Bioanalysis

We provide high-resolution LC-MS/MS bioanalytical support for both small and large molecules, enabling fast, accurate quantitation across a wide range of sample types. Our validated methods, rapid turnaround, and microvolume sampling (as low as 5 µL) support efficient decision-making in early-stage drug development.

Assay Development

We design, develop, and validate high-resolution LC-MS/MS assays for the quantitative analysis of small and large molecules. Our fit-for-purpose methods are optimized for high sensitivity, small sample volumes (≥5 µL), and fast turnaround times.

Includes:

  • Custom LC-MS/MS assay development

  • Fit-for-purpose validation (accuracy, precision, sensitivity, specificity)

  • Microvolume workflows for plasma and tissue collection

High-Throughput Sample Analysis

Our streamlined high-resolution LC-MS/MS workflows are built for speed and scale, enabling rapid turnaround for large sample sets, even from limited volumes. This efficiency supports intensive PK, PD, and biomarker studies without compromising data quality or consistency.

Includes:

  • Automated sample extraction and batch processing

  • Quantitation from microvolumes of sample

  • Plasma, serum, urine, and tissue matrix compatibility

  • Built-in QA/QC procedures and incurred sample reanalysis

  • Fast, reliable data delivery to accelerate decision-making

Biomarker Quantification

We offer targeted high-resolution LC-MS/MS assays for pharmacodynamic (PD) and safety biomarkers, including steroid hormones and other endogenous analytes. Our quantitative biomarker analysis supports decision-making in preclinical and early clinical programs.

Includes:

  • Quantitative analysis of PD and safety biomarkers

  • In-house validated steroid hormone panels

  • Custom assay development for novel biomarkers

Method Transfer & Troubleshooting

We make it easy to transfer or adapt existing LC-MS/MS methods to fit your study needs—whether you're moving from in-house to outsourced testing or troubleshooting a challenging workflow. Our team ensures smooth transitions and quick resolutions to minimize downtime and keep your project on track.

Includes:

  • Transfer protocol development and implementation support

  • Remote or onsite technical consultation and training

  • Root-cause analysis of performance issues (e.g., matrix effects, drift)

  • Method re-optimization and SOP refinement

Why Choose Mass Spectrometry Over Ligand-Binding Assays?

High-resolution mass spectrometry (HRMS) offers a powerful, antibody-free alternative to traditional ligand-binding assays (LBAs). Our LC-MS/MS workflows provide unmatched specificity, faster turnaround times, and greater flexibility—especially for early-stage programs or when reference reagents aren’t readily available.

Advantages of HRMS-based Bioanalysis:

  • No Need for Antibodies
    HRMS quantifies molecules directly, eliminating the cost, lead time, and variability associated with antibody development.

  • Higher Specificity
    Detect and differentiate analytes based on exact mass and fragmentation patterns—ideal for closely related metabolites or isobaric species.

  • Faster Assay Development
    LC-MS/MS methods can be developed and validated in a fraction of the time required for LBA optimization.

  • Multiplexing Capabilities
    Quantify multiple analytes in a single run with minimal cross-reactivity or signal interference.

  • Robust Performance in Complex Matrices
    Maintain sensitivity and accuracy in plasma, serum, tissue, or cell lysates—even without affinity-based cleanup steps.

Whether you're quantifying endogenous biomarkers, peptides, small molecules, or complex metabolites, our HRMS-based assays offer the speed, sensitivity, and data confidence you need to move quickly and decisively.

Let's Talk